The focus of my work directly advances the Center’s core themes of personalized medicine, healthy aging, and disease modeling. By generating patient-specific hiPSC lines and modeling cellular vulnerability in AD, my research enables precision stratification of biologic subtypes and supports individualized therapeutic discovery. The generation of physiologically relevant 3D brain organoids together with highly controlled 2D in vitro models of distinct CNS cell types provide physiologically relevant platforms that capture early pathogenic processes, thereby contributing to innovative disease modeling strategies. Moreover, our emphasis on understanding cellular resilience, intercellular communication, and mechanisms of neurodegeneration aligns closely with the Center’s focus on promoting healthy aging through the identification of potential therapeutic targets and biomarkers.
