The Schulman group is developing molecular biosensor-based technologies for in situ sensing of the spatiotemporal dynamics of soluble proteins throughout a cell culture matrix or organoid. These technologies are designed to be multiplexed and appropriate for high-throughput screening. The Schulman group also is developing molecular biosensors for measuring local mechanical modulus.
Her group also develops biomaterials for integrated sensing and spatiotemporally controlled protein release as well as mechanisms to modulate biomaterial mechanics and density in situ. An overall technology goal is the development of systems for closed-loop feedback control of the biochemical and mechanical developmental niche.
Techniques: In vitro synthetic biology, biochemistry, imaging/longitudinal analysis, optimization/learning, hydrogel design and fabrication.